Vitamin D Receptor Polymorphisms and Susceptibility to Tuberculosis in West Africa: A Case-Control and Family Study
Identifieur interne : 007951 ( Main/Exploration ); précédent : 007950; suivant : 007952Vitamin D Receptor Polymorphisms and Susceptibility to Tuberculosis in West Africa: A Case-Control and Family Study
Auteurs : Liza Bornman [Royaume-Uni, Afrique du Sud] ; Sarah J. Campbell [Royaume-Uni] ; Katherine Fielding [Royaume-Uni] ; Boubacar Bah [Guinée] ; Jackson Sillah ; Per Gustafson [Guinée-Bissau] ; Kebba Manneh [Gambie] ; Ida Lisse [Guinée-Bissau] ; Angela Allen ; Giorgio Sirugo ; Aissatou Sylla [Guinée] ; Peter Aaby [Guinée-Bissau] ; Keith P. W. J. Mcadam [Royaume-Uni] ; Oumou Bah Sow [Guinée] ; Steve Bennett [Royaume-Uni] ; Christian Lienhardt [Sénégal] ; Adrian V. S. Hill [Royaume-Uni]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 2004-11-01.
Abstract
Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.
Url:
DOI: 10.1086/424462
Affiliations:
- Afrique du Sud, Gambie, Guinée, Guinée-Bissau, Royaume-Uni, Sénégal
- Angleterre, Grand Londres, Oxfordshire
- Londres, Oxford
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W. J." last="Mcadam">Keith P. W. J. Mcadam</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sow, Oumou Bah" sort="Sow, Oumou Bah" uniqKey="Sow O" first="Oumou Bah" last="Sow">Oumou Bah Sow</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Guinée</country><wicri:regionArea>Programme National de Lutte Anti-Tuberculeuse, Conakry</wicri:regionArea><wicri:noRegion>Conakry</wicri:noRegion></affiliation></author><author><name sortKey="Bennett, Steve" sort="Bennett, Steve" uniqKey="Bennett S" first="Steve" last="Bennett">Steve Bennett</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lienhardt, Christian" sort="Lienhardt, Christian" uniqKey="Lienhardt C" first="Christian" last="Lienhardt">Christian Lienhardt</name><affiliation></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Sénégal</country><wicri:regionArea>Institute de Recherche pour le Développement, Hann, Dakar</wicri:regionArea><wicri:noRegion>Dakar</wicri:noRegion></affiliation></author><author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><wicri:orgArea>Wellcome Trust Centre for Human Genetics, University of Oxford</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="2004-11-01">2004-11-01</date><biblScope unit="volume">190</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1631">1631</biblScope><biblScope unit="page" to="1641">1641</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Gambie</li><li>Guinée</li><li>Guinée-Bissau</li><li>Royaume-Uni</li><li>Sénégal</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Oxfordshire</li></region><settlement><li>Londres</li><li>Oxford</li></settlement></list><tree><noCountry><name sortKey="Allen, Angela" sort="Allen, Angela" uniqKey="Allen A" first="Angela" last="Allen">Angela Allen</name><name sortKey="Sillah, Jackson" sort="Sillah, Jackson" uniqKey="Sillah J" first="Jackson" last="Sillah">Jackson Sillah</name><name sortKey="Sirugo, Giorgio" sort="Sirugo, Giorgio" uniqKey="Sirugo G" first="Giorgio" last="Sirugo">Giorgio Sirugo</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bornman, Liza" sort="Bornman, Liza" uniqKey="Bornman L" first="Liza" last="Bornman">Liza Bornman</name></region><name sortKey="Bennett, Steve" sort="Bennett, Steve" uniqKey="Bennett S" first="Steve" last="Bennett">Steve Bennett</name><name sortKey="Campbell, Sarah J" sort="Campbell, Sarah J" uniqKey="Campbell S" first="Sarah J." last="Campbell">Sarah J. Campbell</name><name sortKey="Fielding, Katherine" sort="Fielding, Katherine" uniqKey="Fielding K" first="Katherine" last="Fielding">Katherine Fielding</name><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name><name sortKey="Mcadam, Keith P W J" sort="Mcadam, Keith P W J" uniqKey="Mcadam K" first="Keith P. W. J." last="Mcadam">Keith P. W. J. Mcadam</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Bornman, Liza" sort="Bornman, Liza" uniqKey="Bornman L" first="Liza" last="Bornman">Liza Bornman</name></noRegion><name sortKey="Bornman, Liza" sort="Bornman, Liza" uniqKey="Bornman L" first="Liza" last="Bornman">Liza Bornman</name><name sortKey="Bornman, Liza" sort="Bornman, Liza" uniqKey="Bornman L" first="Liza" last="Bornman">Liza Bornman</name><name sortKey="Bornman, Liza" sort="Bornman, Liza" uniqKey="Bornman L" first="Liza" last="Bornman">Liza Bornman</name></country><country name="Guinée"><noRegion><name sortKey="Bah, Boubacar" sort="Bah, Boubacar" uniqKey="Bah B" first="Boubacar" last="Bah">Boubacar Bah</name></noRegion><name sortKey="Sow, Oumou Bah" sort="Sow, Oumou Bah" uniqKey="Sow O" first="Oumou Bah" last="Sow">Oumou Bah Sow</name><name sortKey="Sylla, Aissatou" sort="Sylla, Aissatou" uniqKey="Sylla A" first="Aissatou" last="Sylla">Aissatou Sylla</name></country><country name="Guinée-Bissau"><noRegion><name sortKey="Gustafson, Per" sort="Gustafson, Per" uniqKey="Gustafson P" first="Per" last="Gustafson">Per Gustafson</name></noRegion><name sortKey="Aaby, Peter" sort="Aaby, Peter" uniqKey="Aaby P" first="Peter" last="Aaby">Peter Aaby</name><name sortKey="Lisse, Ida" sort="Lisse, Ida" uniqKey="Lisse I" first="Ida" last="Lisse">Ida Lisse</name></country><country name="Gambie"><noRegion><name sortKey="Manneh, Kebba" sort="Manneh, Kebba" uniqKey="Manneh K" first="Kebba" last="Manneh">Kebba Manneh</name></noRegion></country><country name="Sénégal"><noRegion><name sortKey="Lienhardt, Christian" sort="Lienhardt, Christian" uniqKey="Lienhardt C" first="Christian" last="Lienhardt">Christian Lienhardt</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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